Helleva (lodenafil)
Helleva is the original lodenafil carbonate brand from Cristália in Brazil. Learn what lodenafil is and how it was studied.
- Active ingredient
- Lodenafil
- Form
- Tablet
- Registrant / producer
- Cristália Produtos Químicos Farmacêuticos (Brazil)
Helleva is a Brazilian lodenafil carbonate product. Its professional leaflet identifies an 80 mg tablet and names Cristália as registrant and producer, with Supera RX Medicamentos as the commercial company. That is why Cristália research references and Supera-branded packaging can both belong to the same product context.
Product amount versus research amount
The structured record distinguishes the 80 mg tablet documented by the leaflet from 40 and 80 mg amounts investigated in the phase III trial. A studied amount is not automatically a separately marketed tablet presentation, and the carbonate form should not be compared by simple milligram arithmetic with another PDE5 ingredient.
Lodenafil carbonate is a linked prodrug that releases active lodenafil. Laboratory findings about enzyme potency do not demonstrate superior clinical benefit over Viagra. The ingredient article explains both the chemistry and the placebo-controlled trial.
What the evidence can establish
The four-week phase III study found improved erectile-function outcomes relative to placebo, with more adverse events in the active groups. It had no active-drug comparator and does not establish long-term superiority or freedom from uncommon risks.
The Brazilian leaflet is stronger product-identity evidence than a seller’s company label. It does not establish today’s stock or authorization in another country. Its nitrate and cardiovascular precautions also remain relevant despite the less familiar ingredient name. Read the supplied local information rather than importing directions from a sildenafil or tadalafil pack.
Product record
- Company
- Cristália Produtos Químicos Farmacêuticos Ltda. (Brazilian registrant and producer)
- Strengths
- Lodenafil carbonate 80 mg tablet (Brazilian leaflet)
- Market
- Brazil (Cristália)
- Treatment area
- Erectile dysfunction (ED)
- Record reviewed
- 4 October 2026; source retrieval dates are retained with the evidence
- Commercial company
- Supera RX Medicamentos Ltda. (Brazilian leaflet)
- Research amounts
- 40 and 80 mg investigated in the phase III trial; not two confirmed marketed tablet strengths
- Record reference
- Brazilian leaflet registration 1.0298.0366
Brazilian product and company roles are supported by the leaflet; this does not establish current stock or authorization in other markets.
About lodenafil
Lodenafil carbonate is a prodrug converted to active lodenafil. Laboratory potency is not clinical superiority. Helleva has a Brazilian 80 mg product leaflet; its trial results and company roles are explained in the ingredient guide.
Using a PDE5 inhibitor safely
Never take a PDE5 inhibitor with nitrates, recreational nitrites (“poppers”) or riociguat, and do not combine two ED medicines. Seek urgent medical help for chest pain, an erection lasting more than four hours, or sudden loss of vision or hearing.
Common side effects include headache, flushing, indigestion and a blocked nose.
Sources
3 sources
Checked .
- Helleva Brazilian professional leaflet — Cristália
- Lodenafil carbonate phase III trial — Journal of Sexual Medicine
- Lodenafil carbonate pharmacology — European Journal of Pharmacology