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Lodenafil: ingredient and products

Lodenafil carbonate explained, a PDE5 inhibitor developed in Brazil and sold as Helleva, with its phase III trial results.

Lodenafil carbonate is a PDE5 inhibitor developed and marketed by Cristália in Brazil under the brand name Helleva.

Two molecules in one

Lodenafil carbonate is made of two lodenafil molecules joined together. The body splits it into two molecules of the active drug, a design meant to improve absorption. In laboratory tests lodenafil was roughly twice as potent as sildenafil at blocking the PDE5 enzyme.

Evidence

A Brazilian phase III trial randomized 350 men with ED to placebo, 40 mg or 80 mg. Both doses improved erectile function scores compared with placebo. Reported side effects included headache, flushing, rhinitis and indigestion, the same pattern as other PDE5 inhibitors.

Approval

Lodenafil is used in Brazil. It is not authorized in the EU, UK or US.

Newer PDE5 inhibitors compared · Interactions and urgent symptoms · All ingredients

Products containing lodenafil

  • Lodenafil

    Helleva (lodenafil)

    Helleva is the original lodenafil carbonate brand from Cristália in Brazil. Learn what lodenafil is and how it was studied.

Sources

Checked .

  1. The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction (J Clin Med, 2020) — Europe PMC
  2. Efficacy and tolerability of lodenafil carbonate: a phase III clinical trial (J Sex Med, 2010) — Europe PMC
  3. Pharmacological characterization of lodenafil carbonate (Eur J Pharmacol, 2008) — Europe PMC